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msc osteogenic differentiation medium  (PromoCell)


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    PromoCell msc osteogenic differentiation medium
    Msc Osteogenic Differentiation Medium, supplied by PromoCell, used in various techniques. Bioz Stars score: 95/100, based on 118 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/msc osteogenic differentiation medium/product/PromoCell
    Average 95 stars, based on 118 article reviews
    msc osteogenic differentiation medium - by Bioz Stars, 2026-02
    95/100 stars

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    Schematic conceptualization of this study. IR activated the NF-κB signaling pathway to promote activation and maturation of DCs, amplifying inflammatory signals through the release of pro-inflammatory cytokines. The mDCs triggered oxidative stress of BMSCs, showing increased intracellular ROS levels, inhibited <t>osteogenic</t> differentiation, and enhanced adipogenic differentiation, which accelerated the progression of radiation-induced jaw injury. VitD3-induced tolDCs exhibited IR resistance and anti-inflammatory properties, possessing the therapeutic potential to accelerate bone regeneration in irradiated jaw defects through local administration. (IR: ionizing radiation; mDC: mature dendritic cell; tolDC: tolerogenic dendritic cell; BMSC: bone marrow <t>mesenchymal</t> stem cell; ROS: reactive oxygen species; vitamin D3: vitD3)
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    Schematic conceptualization of this study. IR activated the NF-κB signaling pathway to promote activation and maturation of DCs, amplifying inflammatory signals through the release of pro-inflammatory cytokines. The mDCs triggered oxidative stress of BMSCs, showing increased intracellular ROS levels, inhibited osteogenic differentiation, and enhanced adipogenic differentiation, which accelerated the progression of radiation-induced jaw injury. VitD3-induced tolDCs exhibited IR resistance and anti-inflammatory properties, possessing the therapeutic potential to accelerate bone regeneration in irradiated jaw defects through local administration. (IR: ionizing radiation; mDC: mature dendritic cell; tolDC: tolerogenic dendritic cell; BMSC: bone marrow mesenchymal stem cell; ROS: reactive oxygen species; vitamin D3: vitD3)

    Journal: Stem Cell Research & Therapy

    Article Title: Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury

    doi: 10.1186/s13287-025-04508-x

    Figure Lengend Snippet: Schematic conceptualization of this study. IR activated the NF-κB signaling pathway to promote activation and maturation of DCs, amplifying inflammatory signals through the release of pro-inflammatory cytokines. The mDCs triggered oxidative stress of BMSCs, showing increased intracellular ROS levels, inhibited osteogenic differentiation, and enhanced adipogenic differentiation, which accelerated the progression of radiation-induced jaw injury. VitD3-induced tolDCs exhibited IR resistance and anti-inflammatory properties, possessing the therapeutic potential to accelerate bone regeneration in irradiated jaw defects through local administration. (IR: ionizing radiation; mDC: mature dendritic cell; tolDC: tolerogenic dendritic cell; BMSC: bone marrow mesenchymal stem cell; ROS: reactive oxygen species; vitamin D3: vitD3)

    Article Snippet: BMSCs were co-cultured with mDC-CM and OriCell SD rat bone marrow mesenchymal stem cell osteogenic differentiation basal medium (Cyagen, USA).

    Techniques: Activation Assay, Irradiation